Basic Information
Symbol
NTRK3
RNA Class
mRNA
Alias
neurotrophic receptor tyrosine kinase 3
TRKC
neurotrophic tyrosine kinase, receptor, type 3
GP145-TrkC
gp145(trkC)
NT-3 growth factor receptor
ETS related protein-neurotrophic receptor tyrosine kinase fusion protein
ETV6-NTRK3 fusion
tyrosine kinase receptor C
Trk-C
Neurotrophic tyrosine kinase receptor type 3
TrkC tyrosine kinase
EC 2.7.10.1
EC 2.7.10
Location (GRCh38)
15:87859751-88256993
UCSC Genome Browser
Transcripts
Secondary Structure
MANE Select
NM_001012338.3
Sequence length
20018 nt
GC Content
0.4370
Transcripts
| ID | Sequence | Length | GC Content |
|---|---|---|---|
| NM_002530.4 | GCACUUGUACAUUUCUGCAGCCGCGCGGCGAGCCAUUCGCGGCGGCUGC… | 19976 nt | 0.4372 |
Showing 11 to 11 of 11 entries
Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Forensic Context
No forensic context available.
Genomic Tracks
