Basic Information

Symbol
OPRPN
RNA Class
mRNA
Alias
opiorphin prepropeptide BPLP PRL1 proline rich 1 proline rich, lacrimal 1 PROL1 opiorphin basic proline-rich lacrimal protein basic proline-rich protein proline-rich 1 proline-rich protein 1 Opiorphin prepropeptide Basic proline-rich lacrimal protein Proline-rich protein 1
Location (GRCh38)
4:70397931-70410195 UCSC Genome Browser
Transcripts
NM_001302807.2
BLAST PRIMER
NM_021225.5
BLAST PRIMER
External Database
HGNC NCBI Ensembl UniProt OMIM GTEx

Secondary Structure

MANE Select
NM_021225.5
Sequence length
983 nt
GC Content
0.4232

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-163.4 kcal/mol
Thermodynamic ensemble
Free Energy: -181.11 kcal/mol
Frequency: 0.0000
Diversity: 208.57
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.......(((....(((((......((((((...........(((..(((((((((.((((............(((((((..(((((...))))).....))))))).....(((((.((((.....))))))))).((((((((((((((((((...(((...)))...))))))))))).(((((((.....)))....))))...((((.....)))).............)))))))..(((((((((((..(((..............((((((..........................((((.......))))((((..................)))).....((...))))))))............))).....))))))))))).((.((((.((........)))))).))....(((((((...................)))))))......(((((...................)))))....)))).)))))))))..)))........(((.......))).....................((((..............................))))....((........)).......................((((((.(((((((((((...(((.(((((.......(((........))).(((((((.((((.......(((......)))..........................(((.((...(((((...((.....)).)))))...))..))).....((((((((.........((......)).............(((((((.....)))))))..))))))))..(((.......))).............)))))))))))....))))).))).))))........)))).))).......)))))).....))).))).....)))))....)))......
Thermodynamic Ensemble Prediction
.....,,.,,..,,(((({....,,((((({.......,,{.(((,,(((((((((.((({..,,,.,,,,..{((((((..(((((...))))).....))))))).....(((((.((({.....})))))))).((((((((((((((((((...(((...)))...))))))))))).{{{{,,,...,.}}}....})))...{(((.....)))}.............})))))).,((((((({({{..,{{,,........,,,,..{{(,.,,{,,,................,..,{|{..},,..)))){|{|..................}}}),....{,...},||}},,..............,.....})))))}}}}}.((.((((.{(........}))))).))....(((((((...................)))))))......,((((................,,,),})}....}}}}.}))))))}}..}},........(((.......))).....................,|||}},,....,,....................,|||....||,.......},...................,,..((((((.{{{((({((((...(((.(((((.....((((((..,........((((((({,((.......}|,|}.....,||{.........................,({.,,...(((((...((.....)).)))))...|},.,,)}}...{{({((({,,.....,,((......)),.,.,,.}},...(((((((.....)))))))..,}))))))....},,......))}))}..........))))))......,.))))).))).))))........)))}.))).......)))))).....})}.}}}.....}))))....)))......

Transcripts

ID Sequence Length GC Content
NM_001302807.2 CUUUCUCUUCUUGGACUUUUAAAUUGUGGCUACCUAAAUUGAGUAUCUG… 1039 nt 0.4312
NM_021225.5 CUUUCUCUUCUUGGACUUUUAAAUUGUGGCUACCUAAAUUGAGUAUCUG… 983 nt 0.4232
Summary

This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases neprilysin and aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Forensic Context

No forensic context available.

Genomic Tracks
Track Image