Basic Information

Symbol
PAEP
RNA Class
mRNA
Alias
progestagen associated endometrial protein PEP PP14 GdA GdS GdF PAEG GD MGC138509 MGC142288 glycodelin-A glycodelin-S glycodelin-F progesterone-associated endometrial protein glycodelin PP14 protein (placental protein 14) pregnancy-associated endometrial alpha-2-globulin alpha uterine protein progestagen-associated endometrial protein ZIF-1 PEG placental protein 14 pregnancy-associated endometrial alpha-2 globulin progestagen-associated endometrial protein (placental protein 14, pregnancy-associated endometrial a zona-binding inhibitory factor-1 Glycodelin Placental protein 14 Pregnancy-associated endometrial alpha-2 globulin Progestagen-associated endometrial protein Progesterone-associated endometrial protein Zona-binding inhibitory factor-1
Location (GRCh38)
9:135561756-135566955 UCSC Genome Browser
Transcripts
NM_001018048.2
BLAST PRIMER
NM_001018049.3
BLAST PRIMER
NM_002571.4
BLAST PRIMER
External Database
HGNC NCBI Ensembl UniProt OMIM GTEx

Secondary Structure

MANE Select
NM_002571.4
Sequence length
992 nt
GC Content
0.5776

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-367.1 kcal/mol
Thermodynamic ensemble
Free Energy: -383.26 kcal/mol
Frequency: 0.0000
Diversity: 122.79
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.......((((((((....))).)))))..((((...((((..((((((..((((((((((((.((..((((.((((.(((((((((.(((((((.......)))))))...))))))....))).))....)).))))..)).)))))))....)))))..))))))..)))).............((((....)).))..((((((((((...(((((((((.(((...((((.((((..(((((....(((((...(((((.(((((((((....((((((....(((((....)))))........(((((.(((((((.(((.(.(((......(.(((.((..(((.........(((((.......))))).......)))..))))).)......)))).)))))))).))...))))).........))))))))))))..))).).((((...)))))))).))))))))))..)))).))))...)))...)))))).)))))))))))))(((((..(((((((.(((.((((.(((.(((((((.(((((.(((((.....)))).).))))).))............))))).)))))))...((((....((((((((((....(((((((((((...((((.............(((((((.(.((.((((.(((((((((...))))))......(((.(((((..((((.((((....)))).)).))....))))))))((((((...))))))..))))))))).).)))))))...........))))...)))((((........))))))))))))))))))))))....))))..))))))))))...)))))..(((.((((....)))))))...(((((((((((((........)))).))).)))))).((((((..........))))))...............)))).............
Thermodynamic Ensemble Prediction
.......((((((((....})}.)}))),,{{{{...((((..((((((..((((((((((((.((..((((.(((({(((((((((.(((((((.......)))))))...))))))}.,.,)).))....)).))))..)).)))))))....)))))..))))))..)))).............{(((....)).))..((((((((((...(((((((((.(((.,.((((.((((..(((((....(((((...((({{.(((((((((....((((((.,..(((((....)))))........(((((.((((((((({(.(.(((......(.(({{((..(((......,..(((((.......)))))..,,...)))..))))).)......)))).)))))))).))...))))).........))))))))))))..))).}{((((...)))))))).))))))))))..)))).))))...)))...)))))).)))))))))))))(((((.{(((((((.(((.((((.(((.(((((,,.(((((.(((((.....)))).}.))))).,|,........,,.))))).)))))))...((((....((((((((((....((((((((({{...((((.............(((((((.{.((.((({,(((((((((...))))))......(((.(((((..((((.((((....)))).)).))....))))))))((((((...))))))..))))))))).}.)))))))...........))))...}}||,,,,,}},.,.})}}))))))))))))))))))....))))..)))))))))),}.)))))..({((((((....)))))))...(((((((((((((........)))).)))}}))))).((({{,....,....,|}}}},...............)))}.............

Transcripts

ID Sequence Length GC Content
NM_001018048.2 AGCAUCCCUCUGGCUCCAGAGCUCAGAGCCACCCACAGCCGCAGCCAUG… 926 nt 0.5767
NM_001018049.3 AGCAUCCCUCUGGCUCCAGAGCUCAGAGCCACCCACAGCCGCAGCCAUG… 1021 nt 0.5808
NM_002571.4 AGCAUCCCUCUGGCUCCAGAGCUCAGAGCCACCCACAGCCGCAGCCAUG… 992 nt 0.5776
Summary

This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Forensic Context

No forensic context available.

Genomic Tracks
Track Image