Basic Information
Symbol
PPBP
RNA Class
mRNA
Alias
pro-platelet basic protein
SCYB7
TGB
NAP-2-L1
LA-PF4
MDGF
LDGF
Beta-TG
CTAP3
CXCL7
PBP
b-TG1
TGB1
CTAPIII
NAP-2
platelet basic protein
beta-thromboglobulin
connective tissue-activating peptide III
neutrophil-activating peptide-2
chemokine (C-X-C motif) ligand 7
CTAP-III
TC1
TC2
THBGB
THBGB1
C-X-C motif chemokine 7
CXC chemokine ligand 7
leukocyte-derived growth factor
low-affinity platelet factor IV
macrophage-derived growth factor
neutrophil-activating peptide 2
small inducible cytokine B7
small inducible cytokine subfamily B, member 7
thrombocidin 1
thrombocidin 2
thromboglobulin, beta-1
Platelet basic protein
Leukocyte-derived growth factor
Macrophage-derived growth factor
Small-inducible cytokine B7
Location (GRCh38)
4:73985966-73988276
UCSC Genome Browser
Transcripts
Secondary Structure
MANE Select
NM_002704.3
Sequence length
1307 nt
GC Content
0.3565
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-279.8 kcal/mol
Thermodynamic ensemble
Free Energy:
-308.07 kcal/mol
Frequency:
0.0000
Diversity:
283.82
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....((((((....)))))).(((((.....((((.....))))..((((((((((((...(((.(((.(((((.............)))))...))).))).......(((.((((....(((((.(.(..((((((..((..((((((.((....)).)))).))..)).....((((.((((((((((((......((......)).........(((.(....).))).)))).))).)))))))))((((((..(((((((.((((..(..(((........)))..)..)))).))))((((....((.(((((...))))).))....))))..((...))...)))..))))))))))))....)).))))).)))).)))..((..(((((........)))))..)))))))))).))))..(((((.((((..(((((((((((.....))))))))))).....(((((((((((((((....(((((((((((.....((((((((((..(((....((((.....((((((...(((.((((((((((((...........))))).....))))))).)))....))))))..))))...))).)))))))))).....))..)))).)))))))))))))....((((((((...........(((((((......(((((((((((........))............((((((......)))))).((((...((((.((....(((.((((......)))).)))...)))))).)))).....((((((.((((((........)))))).)).))))...)))))))))..))))))).((((((((.((((.....))))..)))))))).....((((((((..(((..(((((((...((.((...(((((((...(((((((((((..........(((..(((((((((((((.(((((((((..........)))))))))......((((((((((...(((.((((((((.....)).)))))))))....))))))))))(((((((((.....(((..((.......))..)))......))))).))))...........))))))))))))).))))))))))).)))...)))))))...))))....)))))))))))))))))).......)))))))).))))))).........................................))))))))).....(((....)))........))))).....
Thermodynamic Ensemble Prediction
.....,(((((....)))))}.(((({.....((((.....))))..((((((((((((...(((.(((.(((((.............)))))...))).)))....,..(((.((((....(((((.(.,..((((((..((..((((((.((....)).)))).))..)).....((((.((((((((((((..,,..,|,.....||,,,.....}}|||{....,,}...))))}}}),)})))))))((((((..(((((((.((((..{..(((.,......)))..}..)))).))))((((....((.(((({...})))).))....))))..{{...}}...)))..))))))))))))....}).))))).)))).))).||{..(((((........)))))..}}))))))))}}))}..,{{{(,((((..(((((((((((.....))))))))))).....{{||||{((((((({..,,(((({{{{,,,{||,,||||||||{{{{((({,...{{{.,}},.|||||,.,||,.,,|||||||{{{.|||||,...,},,,,.....,}}}}}}.}}}...|},|||,{((({,{{{,....,,}}..,.)))))})).,))}||||||||)))))||,,..((((((((.......,...(({{(((,,,.,,((((,,{{,{{.....,,,)),.{(({...,}}|,{(((......))))},.,,,,...{{{,.{,....|||,||{{....,.)))}.}}}...}}}}},.}))}..,..{{{(((,({((((..,,,,,,}}}}}}.}},,})),..}})))))),.,)))}))),|,,{{{{,.,,,,.,,.,,,,|.,,}}}))),.....((((((((..{{{..(((((((...((.({...(((((((...(((((((((((...........,,..(((((((((((((.(((((((((..........))))))))).....{((((((((((...(((.((((((({.....}).)))))))))....))))))))))}.,,(((((.......{,,{(,,{,...,,...,,..,,},))))},|||,.......}}}}))))))))))))).}}.)))))))).)))...)))))))...}),,.,..)))))))}}})))))))).......)))))))).}}}}}}),,,,..,,,,,|||||......,,,,...............}}}}}}}},.....{{{....))}........))))).....
Transcripts
| ID | Sequence | Length | GC Content |
|---|---|---|---|
| NM_002704.3 | ACUUAUCUGCAGACUUGUAGGCAGCAACUCACCCUCACUCAGAGGUCUU… | 1307 nt | 0.3565 |
Summary
The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014]
Forensic Context
No forensic context available.
Genomic Tracks
