Basic Information
Symbol
PRB2
RNA Class
mRNA
Alias
proline rich protein BstNI subfamily 2
PRPPRB1
Ps
cP7
IB-9
basic salivary proline-rich protein 2
Basic proline-rich peptide P-E
con1 glycoprotein
proline-rich protein BstNI, subfamily-2 (parotid size variant)
salivary proline-rich protein 2
Basic salivary proline-rich protein 2
Salivary proline-rich protein
Con1 glycoprotein
Location (GRCh38)
12:11391540-11501041
UCSC Genome Browser
Transcripts
Secondary Structure
MANE Select
NM_006248.4
Sequence length
1431 nt
GC Content
0.5772
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-380.9 kcal/mol
Thermodynamic ensemble
Free Energy:
-409.15 kcal/mol
Frequency:
0.0000
Diversity:
471.66
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((((((((((.(((..(((...((.(((((..(((((((...((((.(((((((.(((((((((.((((.((((((...))))))........(((.....)))....(((......)))...(((......)))...(((....)))((..((......))..))............(((((.........(((.(((.........(((((...........(((((.....)))))..))))).........))).))).........)))))..........(((((......((((..((((......(((((.((....))....((((....(((....)).)....))))....((((.........(((.(((........((((((...........(((((.....)))))..))))))........))).))).........))))...........)))))......))))..))))......))))).((....))....(((((..........((.(((.....)))))(((.(((..((((((((((.((....((....))....)).......((.(((.....)))))..(((((......((((...((....))...))))............(((((......((((..((((......(((((.((....))....(((((..........((.(((.....)))))...(((.......((((...((....))...)))).......)))..((.(((.....)))))..)))))......((((...((....))...))))............)))))......))))..))))......))))).((....))....)))))..........))))).))...)))..))).)))......((((...((....))...)))).............(((((.....)))))..)))))....((((((...((....((....)).......))...)))))).......(((..((((.....))))..)))...))))))))).))))..((....)).)))))))))))....))).....))))....)))))..)).....))).)))))))))..((((((............((((((.....((((((((((((............(((...))).))))))))))))........)))))).....((((((.....)))))).).)))))..(((((..((((((.(((((((.....((((((...(((((...........)))))....)))))))))(((.((....)).)))...))..)).))))))....)))))...............)))))..........................
Thermodynamic Ensemble Prediction
.(((.,{,((((((.(((.{({(...((,((((({..{{,||{,,.{{{||{{((({{{({(((((((.((((.((((((...))))))..,,.....,|,,..,}}}}}.||{,,|......,,,,|}|..,.}}}||,..||{....)))|},},}},....|((((,......,,,...(((((......{{{(,,.(({.........(({{{...........(((((.....)))))..|||||....,{{{{|...||,...,,....))}},....,....,|||||......,(({..{(({.....,}}}||,||....|}....||{|,...,{,...,(({{{...,||,....|,,...,.}}||||...||,...,,...,|||{{...........(((((.....)))))..||||||...,,{{{|...||,...,,....)),},....,....,|||||......,(({..{|||.....,)))},,||....||....|||||....,,....((,(({.....}}},|{{..,,,}.|.||||||...||....}}....||,,,..........((.(((.....)))))..|||||....{{{{{{...||,...{{....)),,....,,....,}||||......,{{|..{|||.....,)))},,||....||....||||,.....,,,..((.(((.....)))))...|||.......||||...||....}}...,||},,.....,....((.(((.....)))))..|||||....{{{{{|...||....{{....)),,,...,,....,))}||......,{{|..{|||.....,))),,,|}....,,....||}}}..,,,,....|||||.||...|||.,{{...,,},)..,||||.,.||,...}}....||||,...........(((((.....)))))..|||||....{{{{{|...||,...{{....)),,....,,,...,}||||......,{{|..{|||.....,))),,}}}....,,...,||,|,.{{{((...{(({((|.{,..{{{{....{{{{,...{,{{{....||,..,||....))},..,,},.....|,,||,......},,...((((((.....((((((((((((....,,...|..{{|...))}.))))))))))))..,.....)))))).....}|||)))}...))))),.}.}))),..|,}||}|...|||,,.}}}}}}{{.|{{{{...,...,,.}}}}}.})..{{{.{{.{((((.{.(((((.......{((({|,.....({(......))).....))))))....)))))..)))))}}.,,,..............,}}}))..
Transcripts
| ID | Sequence | Length | GC Content |
|---|---|---|---|
| NM_001367912.2 | AGCACAGAGUUGGGAGUGACUCCAGAGCCUCCUGCAAGAUGCUGUUGAU… | 1986 nt | 0.5856 |
| NM_006248.4 | AGCACAGAGUUGGGAGUGACUCCAGAGCCUCCUGCAAGAUGCUGUUGAU… | 1431 nt | 0.5772 |
Summary
This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats, polymorphic cleavage sites and polymorphic stop codons have been identified. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, May 2023]
Forensic Context
No forensic context available.
Genomic Tracks
