Basic Information

Symbol
SFTPC
RNA Class
mRNA
Alias
surfactant protein C SP-C PSP-C SMDP2 BRICD6 BRICHOS domain containing 6 surfactant, pulmonary-associated protein C SFTP2 SP5 pulmonary surfactant apoprotein-2 SP-C pulmonary surfactant-associated proteolipid SPL(Val) Surfactant protein C Pulmonary surfactant-associated protein C Pulmonary surfactant-associated proteolipid SPL(Val)
Location (GRCh38)
8:22156913-22164479 UCSC Genome Browser
Transcripts
NM_001172357.2
BLAST PRIMER
NM_001172410.2
BLAST PRIMER
NM_001317778.2
BLAST PRIMER
NM_001317779.2
BLAST PRIMER
NM_001317780.2
BLAST PRIMER
NM_001385653.1
BLAST PRIMER
NM_001385654.1
BLAST PRIMER
NM_001385655.1
BLAST PRIMER
NM_001385656.1
BLAST PRIMER
NM_001385657.1
BLAST PRIMER
NM_001385658.1
BLAST PRIMER
NM_001385659.1
BLAST PRIMER
NM_001385660.1
BLAST PRIMER
NM_003018.4
BLAST PRIMER
External Database
HGNC NCBI Ensembl UniProt OMIM GTEx

Secondary Structure

MANE Select
NM_001317778.2
Sequence length
839 nt
GC Content
0.6079

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-340.5 kcal/mol
Thermodynamic ensemble
Free Energy: -353.94 kcal/mol
Frequency: 0.0000
Diversity: 170.41
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((((........((((..((((((....((((((......((((..(((((((..((.((((..((.(((....))))).)))))))))))))..))))))))))..))))))...))))....(((.....))).....(((((((((((((((.((((((..((((.((((.(((((((.((((((((((....((((((...((((((....(....)....)))))))))))))))))...)))))........)))).)))))))))))..)))).)).)))).....)))))))))))))))))).))(((((((((((((..(((((.....)))))((((....))))...........(((((...))))).....(((((.((((.((..(((.((((....)))))))..)).....(((((..((.(((((.((((.....))))...(((((.(((((...(((((..(((((...))))).)))))((((((((((.......))).)).))))).((((((.......))))))))))).)))))(((.(((((.(((...))).)))))))).........))))))).))))).)))))))))))))))))).)))).(((((((.........(((((((((.....((((((((((.....)))))).)))).....(((((((((((((((.((((.....(((((((((......)))).))))).......).)))..))))))))))))))))))).))))).((((....))))...................)))).))).........
Thermodynamic Ensemble Prediction
(((((((((...((...((....||.||.{(.,(,{{.((((((((({{..(((((((..((.((((..(,{(((....))))).)))))))))))))..}},||...,},,))))))))}}},)}.,,,....,,,,}}.....(((((((((((((((.((((((..((((.((((.(((({((.((((((((({...,((((((...((((((....(....)....)))))))))))))))))}..})))).,,.....})),})))))))))))..)))).)).)))).....)))))))))))))))))).}}(((((((((((((((((((((({.......((((((.{(({,...{|......{{{{|,..})))),.}}))))})))))))))}.(((.((((....))))))),,{{....,|.}}{{((((((.((...((((..........(((((.(((({...{((((..((((,...))))).))))}((((((((((.......))).)).))))).((((((.......)))))),)))).)))))(((.(((((.(((...))).)))))))).............))))...)).)))))).}))))))))))},))).{,,{(((...{,....,{(((((((...,,((({{{(((({...|)))))).}}}).....(((((((((((((((.((((.....(((((((({......)))).))))).......}.)))..))))))))))))))))))).}}}))}}|||...,))}||..,..,,,......,,,.}))).))).........

Transcripts

ID Sequence Length GC Content
NM_001385658.1 AGUCCAGCCCUUUGUCUAACAAAUGAGGAAACUGAGGCCCCCUAAGCUU… 1535 nt 0.5837
NM_001385659.1 ACACAGAAGGGGUGGCCACCGUGGGGCUGUCCAUCACUCAGGGCUCUCA… 1322 nt 0.5998
NM_001385660.1 AGUCCAGCCCUUUGUCUAACAAAUGAGGAAACUGAGGCCCCCUAAGCUU… 1394 nt 0.5811
NM_003018.4 GAGGAGAGGAGAGCAUAGCACCUGCAGCAAGAUGGAUGUGGGCAGCAAA… 857 nt 0.6056
Showing 11 to 14 of 14 entries
Summary

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010]

Forensic Context

No forensic context available.

Genomic Tracks
Track Image