Basic Information

Symbol
TBCA
RNA Class
mRNA
Alias
tubulin folding cofactor A tubulin-specific chaperone a CFA TCP1-chaperonin cofactor A chaperonin cofactor A epididymis secretory sperm binding protein Tubulin-specific chaperone A Tubulin-folding cofactor A
Location (GRCh38)
5:77691166-77868780 UCSC Genome Browser
Transcripts
NM_001297738.2
BLAST PRIMER
NM_001297740.2
BLAST PRIMER
NM_004607.3
BLAST PRIMER
External Database
HGNC NCBI Ensembl UniProt OMIM GTEx

Secondary Structure

MANE Select
NM_004607.3
Sequence length
661 nt
GC Content
0.3964

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-142.8 kcal/mol
Thermodynamic ensemble
Free Energy: -155.81 kcal/mol
Frequency: 0.0000
Diversity: 236.2
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.......(((((((...))))).))....(((((.(((..(((((((...((((...........)))).)).)).)))))).))((((.((......(((......))).......)).))))(((((((((.(((((((..(((((...((((.((((((((...((((((.......(((.(((...(((.....(((....((((....))))....))).((((((...(((..(((((((((............((((((((..((((((((....(((((....)))))..(((.(((((((((((((.....)))).))))..........((.(((.....)))))((((((.....((..((...((((((((((....)))))...))))).))))......))))))))))).)))(((((.......)))))))))))))))))(((((.(((((..(.(((((.(((......))).))))).)..))).)).)))))..........)))).............)))))))))..)))...))))))....)))...))).))).......)))))).)))))))).))))....)))))..)))))))))))))))).......((((.....))))...)))..
Thermodynamic Ensemble Prediction
.......(((((,(,{{|||||{{{,(,,..(({.(((..(({((((...((((...........)))).)).)).)))})).})},,|.,|..}}}}|||}...{,|}....,,..}}.})))|||||,,(({(({(((({{((((....((({,((,{,,,....,{|||...,....,,,.,,,..{((({..,{((({.{{,((,,.{,,,||{{{{{{{{(,,(((..,((({{((((,,,{{...,,,..({({(((({.(((.(((((((((({,(((((....)))))...,.,||.}}}}))}}|,}}}.,,,.|{{{{{{...,........((({{......))}}}.............,...}}}}}}|))}}}))),}}}..},}....)))))...))))),,...)))..)))))))))))......)),),)),))))))}},||}|||||},|}|||||}|||}}}|{{{||{.,||,{|{.{{|{||{||.,,.}))}}))))))),}}}}}}}}....,|||||||||..,,,..{||||,,....|{{{{.}},.},|.,,,,,,||||},,}}}}}},,.,,}}....}}}}}..})})}},,}}}})))),.....}}}}}....,}}.)})))))}.
Summary

The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Forensic Context

No forensic context available.

Genomic Tracks
Track Image