Basic Information

Symbol
BAX
RNA Class
mRNA
Alias
BCL2 associated X, apoptosis regulator BCL2L4 BCL2-associated X protein BCL2 associated X protein apoptosis regulator BAX BCL2-associated X protein omega Baxdelta2(G8)-RFS protein Baxdelta2G9 Baxdelta2G9omega Baxdelta2omega bcl-2-like protein 4 bcl2-L-4 Apoptosis regulator BAX Bcl-2-like protein 4 Bcl2-L-4
Location (GRCh38)
19:48954815-48961798 UCSC Genome Browser
Transcripts
NM_001291428.2
BLAST PRIMER
NM_001291429.2
BLAST PRIMER
NM_001291430.2
BLAST PRIMER
NM_001291431.2
BLAST PRIMER
NM_004324.4
BLAST PRIMER
NM_138761.4
BLAST PRIMER
NM_138762.2
BLAST PRIMER
NM_138763.4
BLAST PRIMER
NM_138764.5
BLAST PRIMER
External Database
HGNC NCBI Ensembl UniProt OMIM GTEx

Secondary Structure

MANE Select
NM_138761.4
Sequence length
795 nt
GC Content
0.6075

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-332.4 kcal/mol
Thermodynamic ensemble
Free Energy: -349.15 kcal/mol
Frequency: 0.0000
Diversity: 150.56
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((.((((.(((((((.(((.......))).).)))))).))))..))((((((((((....(((((.(((.(.(((((.((((((((((((((......(((((.....))).))......)))))).)))))))).))))).).))).)))))...))(((((..(((((((((((((.(((((.(..(((((((..((((((((((((....(((((.((.....(((((((....).))).))).....)))))))..)))..(((.((((((.((((((...(((.((..(((.(((.((............)))).).)))..)).))).....))))))..))))))..)))..(((((........(((((.((....)))))))........))))).......((((((.((......)).)))))))))))))))...((.((((..(((...))).)))).)).((((.....))))(((.(((((....)))))..)))....)))))))).)))))...)))))))))))))........))))).....(((..((((.((.......)).))))...))))))))))).(((((.((((((......))))))(((.(.((((((((.(.(((...(((.....(((((((((((...))))).........)))))))))))).)))))))).).).)))...((((((((((((.(((...))).)))).)))))))))))))(((((((((((((.....))).))))))))))...
Thermodynamic Ensemble Prediction
((.((((.(((((((.(((.....,.))).).)))))).))))..))((((((({,{..{.(((((.(((,(.(((((.((((((((((((((.....{(((((.....))).)},}....))))))))))))))).))))).).))).)))))...},((((({,(((((((((((((.(((((.(..(((((((..((((((((((((....(((((.((.....(((((((....).))),,))...,.)))))))..))),.(((.((((((.((((((...(((.((..(((.(((.((,.......,,,.}.)).).)))..)}.))).....))))))..))))))..))).,(((({........(((({{({....}))))))........})))).......((((((.((......)).)))))))))))))))...,{.{(((..(({...,)),)}}}.}},((((..,{{}}}}|||,{{{{|....)))))..))),...)))))))),)))))...))))))))))))).,,.....)))))....,(((..((((.((.,.....)).))))...))))))))))).(((((.((((((......))))))(((.(.((((((((.(.(((...,{.......,{(((((,,{,,..,,,,...,,,...,)))))))}))),,))))))).).).)))...((((((((((((.({,...,)).)))).)))))))))))))(((((((((((((.....)))}))))))))))...

Transcripts

ID Sequence Length GC Content
NM_001291428.2 GCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGG… 844 nt 0.6102
NM_001291429.2 GCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGG… 1360 nt 0.6007
NM_001291430.2 GCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGG… 1213 nt 0.5977
NM_001291431.2 GCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGG… 596 nt 0.6040
NM_004324.4 GCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGG… 1412 nt 0.6006
NM_138761.4 GCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGG… 795 nt 0.6075
NM_138762.2 UCACGUGACCCGGGCGCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGG… 195 nt 0.7436
NM_138763.4 GCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGG… 648 nt 0.6034
NM_138764.5 GCGCUGCGGCCGCCCGCGCGGACCCGGCGAGAGGCGGCGGCGGGAGCGG… 756 nt 0.6045
Summary

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Dec 2019]

Forensic Context

No forensic context available.

Genomic Tracks
Track Image