Basic Information

Symbol
TNNI2
RNA Class
mRNA
Alias
troponin I2, fast skeletal type FSSV DA2B fsTnI troponin I, fast-twitch skeletal muscle isoform troponin I fast twitch 2 troponin I, skeletal, fast arthrogryposis multiplex congenita, distal, type 2B troponin I type 2 (skeletal, fast) AMCD2B DA2B1 troponin I, fast skeletal muscle Troponin I, fast skeletal muscle Troponin I, fast-twitch isoform
Location (GRCh38)
11:1838981-1841680 UCSC Genome Browser
Transcripts
NM_001145829.2
BLAST PRIMER
NM_001145841.2
BLAST PRIMER
NM_003282.4
BLAST PRIMER
External Database
HGNC NCBI Ensembl UniProt OMIM GTEx

Secondary Structure

MANE Select
NM_003282.4
Sequence length
751 nt
GC Content
0.6138

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-290.6 kcal/mol
Thermodynamic ensemble
Free Energy: -302.47 kcal/mol
Frequency: 0.0000
Diversity: 179.82
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....((((((((((.(.(..(((((((((((..((((......((.((((.((((...)))).)))).)))))).)))))).)))))..).))))....(((((.....)))))((((.((.(((((....)).))).))))))...))))))).((((...(((.....((((..((((.((.(..(((((....(((((......((((((.((...))))))))(((((...(((.(.(((((((((....((((.....((((.....((((((((((.......)).))))))))....))))..))))))))))))).)..))))))))....(((((.....)))))...........((((.....)))).)))))((((((.((...((.(((((((.((.(.(((.(((.((((........))))))).)))..((((((...(((.((.(.(((((...))))).).))))).)))))).(((((...))))).....................).)).)))(((((((...)))))))(((((((....(((((((.........((((((.......))))))....)))))))...))).))))...)))).)).))))))))...(((((....(((((....(((((((.........)).)))))..)))))))).)))))))).))..))))..))))....))))))).......((((....))))...
Thermodynamic Ensemble Prediction
.....((((((((({,(.{..(((((((((((..((((......((.((((.((((...)))).)))).)))))).)))))).)))))..,.))))....(((((.....)))))((({{((.(((((....)).))).))))))...))))))).((((...(((....,({((..{{||.||,({,(((,,....,(((..{..{{((((((.((.,,||||}||.(((((...(({.(.(((((((((....((((.....((((.,...((((((((((.......)).))))))))....)}}}..))))))))))))).)..))))))))....(((((.....))))).{{.......}|.....,..,|||,|||||(((((..((....||,|||||,....,}|{{,|{{,(({(,,...,,.,}}||}|{|||..((((((.,.(((.((.(.(((({...})))).).)))))}))))))....|,..})))))},,,..}}.,|.,........{{,|||||{({{(((,,.}))))}}{{(({((....{{{{{|{..,......{{{(((....,,,||||||....|||}}})...))).,)))},.}))).)))})})))))}.,,)})})}}}(((((....((((({{.,.......)).)))))..)))))}}}.))))))))}),,}}})),,)))),},.))))))).......((((....))))...
Summary

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Forensic Context

No forensic context available.

Genomic Tracks
Track Image