Basic Information

Symbol
TNNI3
RNA Class
mRNA
Alias
troponin I3, cardiac type TNNC1 CMH7 cTNI cardiomyopathy, dilated 2A (autosomal recessive) troponin I type 3 (cardiac) troponin I type 3 CMD1FF CMD2A RCM1 troponin I, cardiac muscle Troponin I, cardiac muscle Cardiac troponin I
Location (GRCh38)
19:55151767-55157773 UCSC Genome Browser
Transcripts
NM_000363.5
BLAST PRIMER
External Database
HGNC NCBI Ensembl UniProt OMIM GTEx

Secondary Structure

MANE Select
NM_000363.5
Sequence length
843 nt
GC Content
0.6109

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-338.1 kcal/mol
Thermodynamic ensemble
Free Energy: -353.93 kcal/mol
Frequency: 0.0000
Diversity: 233.76
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....((((((((.((((((((((.((((((.(..((((...(((((...))))).....)))).)))))))((((((((((((....((((...(((((((((((((.(..(((((((((((...(((((((.((.((.((((.((((((.((((.((((((.((..((.((((.......))))))..))(((((..((.(.((((((((((((.....(((.((....))..))).(((.(.(((..(((.....)))....((((......)))).....(((((.((....)).)))))((((...)))).(((....)))...))).).)))))))))))))))).)).....))))).))))....)).))))))))))...)))))).)))))))))...)))...(.(((((((..((.(....)))..))))))).)(((..((((......(((..(......)..)))..))))..))).....(((((..........(((((.(((.((((((........)))))).))).))))).(((..((....)).)))....(((((((((.......)))))))))..(((........)))(((...((((((((((((((.((....))))).))..))))))).))...))).)))))...)))))).))..).).))))....)))).))))))))...((.(((.((...))..))).)).)))))...)).)))))..........)))))))).))..((((((((.......((....))....))))))))))))))))....(((((......)))))....
Thermodynamic Ensemble Prediction
....(((((((({(((((({{((.{(((((.(,.({((...(((((...}))}}.....)))).))))))}{||(((({({{{....((((...{((((((((((((,,..(((((((({((...(((((((.((.((.((((.((((((.((((.(({(({.{({{((.((({..,,,.,))}}))..,.||{{{..((,(,((((((((((({..{{.((((((,...||..,|}.|{,,,.,,,..(({.....}))....,((({({(((.,,......,{{(({..,,.,{{{{{|,,{((|...}))}.}))},}})))..})),.))))))))))}))))))),))}....))))),))))},,,)).))))))))))...)))))).)))))))))..,)}|,,(({(((((((..((.(....)))..))))))).||{({(((((,.{..(((({,{...........,..,.,...,,,....,))}}}..}..}}.}}|||{{.{{,.((((((........)))))).|}}.}}}}},||{..{{....}},}})},,,(((((((((.......))))))))).,(({.,...,,.)))}(((({(((((((((((((,{((....))))).))..))))))).))...))))))))},,.)))))).)).,}.).,))}....)))).)))})))),,|((.(((.({...})..))).)).|||||...||,||||},,........})))}}},,)}..|||||||{..,,,,,,,,...,|....})))))))))))))))....(((((......)))))....
Summary

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020]

Forensic Context

No forensic context available.

Genomic Tracks
Track Image