Basic Information

Symbol
TPM1
RNA Class
mRNA
Alias
tropomyosin 1 chromosome 15 open reading frame 13 cardiomyopathy, hypertrophic 3 tropomyosin 1 (alpha) C15orf13 CMD1Y CMH3 HEL-S-265 HTM-alpha LVNC9 TMSA tropomyosin alpha-1 chain epididymis secretory protein Li 265 sarcomeric tropomyosin kappa Tropomyosin alpha-1 chain Alpha-tropomyosin Tropomyosin-1
Location (GRCh38)
15:63042481-63071915 UCSC Genome Browser
Transcripts
NM_000366.6
BLAST PRIMER
NM_001018004.2
BLAST PRIMER
NM_001018005.2
BLAST PRIMER
NM_001018006.2
BLAST PRIMER
NM_001018007.2
BLAST PRIMER
NM_001018008.2
BLAST PRIMER
NM_001018020.2
BLAST PRIMER
NM_001301244.2
BLAST PRIMER
NM_001301289.2
BLAST PRIMER
NM_001330344.2
BLAST PRIMER
NM_001330346.2
BLAST PRIMER
NM_001330351.2
BLAST PRIMER
NM_001365776.1
BLAST PRIMER
NM_001365777.1
BLAST PRIMER
NM_001365778.1
BLAST PRIMER
NM_001365779.1
BLAST PRIMER
NM_001365780.1
BLAST PRIMER
NM_001365781.2
BLAST PRIMER
NM_001365782.1
BLAST PRIMER
NM_001407322.1
BLAST PRIMER
NM_001407323.1
BLAST PRIMER
NM_001407324.1
BLAST PRIMER
NM_001407325.1
BLAST PRIMER
NM_001407326.1
BLAST PRIMER
NM_001407327.1
BLAST PRIMER
NM_001407328.1
BLAST PRIMER
NM_001407329.1
BLAST PRIMER
NM_001407330.1
BLAST PRIMER
NM_001407331.1
BLAST PRIMER
NM_001407332.1
BLAST PRIMER
NM_001407333.1
BLAST PRIMER
NM_001407334.1
BLAST PRIMER
NM_001407335.1
BLAST PRIMER
NM_001407336.1
BLAST PRIMER
NM_001407337.1
BLAST PRIMER
NM_001407338.1
BLAST PRIMER
NM_001407340.1
BLAST PRIMER
NM_001407341.1
BLAST PRIMER
NM_001407342.1
BLAST PRIMER
NM_001407344.1
BLAST PRIMER
External Database
HGNC NCBI Ensembl UniProt OMIM GTEx

Secondary Structure

MANE Select
NM_001018005.2
Sequence length
1217 nt
GC Content
0.5094

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-385.4 kcal/mol
Thermodynamic ensemble
Free Energy: -407.14 kcal/mol
Frequency: 0.0000
Diversity: 372.51
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((....((((((((((.((.((.(((.((((((((...)).((....))..((((....(((((((((.((((((((..(.((...((.(((........)))))...((((..((((((((((((......)))))..))))))).))))(((....)))..)).)..))))))))....(((..(((..(((((........))))).)))..)))..............(((((((...(((((.((...((....((((...(((((((.....((((((......)))).))((((..........))))......(((..(((..(.((((((((.....(((((((.(((.(((((((.((......)).))))).))...))))))))))....(((((((...)))))))..)))))))).)..)))..))).)))))))...))))...))..)))))))..).))...))))..................(((...(((((.........))))).....)))((((...)))).....(((.....)))........)))).)))))....)))).(((....)))))))).).)))..)).)).)))))))))).)))))....((((((((..((((((..((((.(((..............(((((............))))).(((.(((.(((..(((((.((....(((..(((((((((((....(((((.(((....))).)))))..((((((.(.(((((.((.(((((.((((((((((..((((((((((((......)))).....(((((..((.((((((((((..(((((((((..((((...)))).))))).......((((.....))))......))))(((......)))))))....))))))))..))))).))))))))..))))))........)))).)).))).))))))).).)))).)).))))))))....)))..)))....)).)))))..))).))).)))...))).))))..)))))).....))))))))........(((((.(((.((..((((((.......)))))).((((((.......))))))...............(((((((((((.((....)).))))...)))))))....)).)))..))))).......
Thermodynamic Ensemble Prediction
{{{{...{{,({((({(((((((,{.{{{,{{{,{{((((,({,(({.,.,,.|,|||....}|||....|}||||{{((,...})).,||((((........))))}...{(((..((((((((((((......)))))..))))))).)))}))))),)|||,.......)))))))).,}..,}))))(((((((({({{({.(((({((((((.{(,.............}}))))))...,.{{..((((.......(((((((((.......((((((((((...((((((((,((((..........)))}.....,||,..(((..(.(((((((({{,..(((((((.(((.(((((((.((......)).))))).))...)))))))))).,..(((((((...))))))),})))))))).)..))).((((((((((((.(((((((..{{,..,|}}|(((((((..(((((..................{((...{((((.....,,..}}}}}.,,{{|||(((,...|||}......(({.,{{.|.........,.))})))},,,..}}})}))})).,}.,}.((..((((.......))).)..)))))))..))))))),..((({....)))).(((((((.(,.,...........(((((............))))).{{{{,||,.{{..(((((((....{{{{,,((({{{(,,,{(((,(({{((({,{..{({((,((((,.,,{((({{..,,({{(..,{{||||.{|{|||}||||||||||{{,.,.......,{{{,{,,,,{{{.,{{,||||||,..|,,,.{|||||{,,||||...)))).))}),.})}}.}}}}|..|||}|.)},,}..)})))}.......,,.})))),)))},)))))}}))),,.}}))))))}.,},))))})).)})))))||,..,}},.)))))))..))))).))))))),,...))))))))...)))))............))))).,))))))))))))),|,,...((((((........)))))).})))).)).}}}|(((((,....,.}}}}}}.((((((.......))))))..........,....,,,||||||||,,},.{{{{{{{{....)))},,,,}}},...))))))))........
Summary

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y. [provided by RefSeq, Jun 2022]

Forensic Context

No forensic context available.

Genomic Tracks
Track Image