Basic Information

Symbol
TRPM7
RNA Class
mRNA
Alias
transient receptor potential cation channel subfamily M member 7 CHAK1 LTRPC7 TRP-PLIK transient receptor potential cation channel, subfamily M, member 7 ALSPDC CHAK LTrpC-7 LTRPC ion channel family member 7 channel-kinase 1 long transient receptor potential channel 7 transient receptor potential-phospholipase C-interacting kinase Transient receptor potential cation channel subfamily M member 7 Channel-kinase 1 Long transient receptor potential channel 7 LTrpC7 EC 2.7.11.1
Location (GRCh38)
15:50552473-50686797 UCSC Genome Browser
Transcripts
NM_001301212.2
BLAST PRIMER
NM_017672.6
BLAST PRIMER
External Database
HGNC NCBI Ensembl UniProt OMIM GTEx

Secondary Structure

MANE Select
NM_017672.6
Sequence length
10382 nt
GC Content
0.3954
Summary

This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017]

Forensic Context

No forensic context available.

Genomic Tracks
Track Image