Basic Information
Symbol
BPIFA1
RNA Class
mRNA
Alias
BPI fold containing family A member 1
LUNX
bA49G10.5
SPLUNC1
palate, lung and nasal epithelium carcinoma associated
palate, lung and nasal epithelium associated
NASG
PLUNC
SPURT
BPI fold-containing family A member 1
ligand-binding protein RYA3
lung-specific protein X
nasopharyngeal carcinoma-related protein
palate lung and nasal epithelium clone protein
protein Plunc
secretory protein in upper respiratory tracts
short PLUNC1
tracheal epithelium enriched protein
von Ebner protein Hl
Lung-specific protein X
Nasopharyngeal carcinoma-related protein
Palate lung and nasal epithelium clone protein
Secretory protein in upper respiratory tracts
Short PLUNC1
Tracheal epithelium-enriched protein
Von Ebner protein Hl
Location (GRCh38)
20:33235995-33243311
UCSC Genome Browser
Transcripts
Secondary Structure
MANE Select
NM_130852.3
Sequence length
1075 nt
GC Content
0.5470
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-385.2 kcal/mol
Thermodynamic ensemble
Free Energy:
-405.92 kcal/mol
Frequency:
0.0000
Diversity:
276.12
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(.(((((((((.((((((.(..((((.((((((((((((((((...((...(((((......(((((....)))))(((((((((....((((.((((.....(((((...))))))))).)))))))))))))..(((..((.(((..(((((((((((........((((((((.(..((.((((((((....(((.((....)).))))))))..))).))..(((((((..((((..(((((.(.....).))))))))))))))))..((((....))))(((.(.((....)).).)))..(((((.(((.....((((((((...((((((..((((..((..((((...(((((((((...((.......))..))))))))).....((((...)))).((((...)))).))))..))....))))..)))))).)))))))).........((((..((.....(((.((..(((...)))...)).)))...))..))))(((((((((((((.((((((....))))))........((((.........))))(((((((..(((((.(((((((.....)))))))((((....))))..((((...)))).)))))..)))))))..)))))))))))))))).))))))))))))))((((...))))...((((..((((.(((.....)))))))...)))))))))))))))..))).))))).)))))))...)))).))))))((((((((((((((...))))(((((..........)))))((((..((((((....)))))).))))..))))))))))(((((....(((((((((((((.(((((((((......))))..((((....)))).((((......(((.......)))..))))........))))))))).))))))))).....)))))........))))))((((......))))..))))..)))))))))))))))))(((((((((........)))))))))..............((.........)).
Thermodynamic Ensemble Prediction
{.(((((((((.((((((.(..((((.((((((((((((((((...{,.,.(((((......,{(({....}))||(((((((((.,,,,{((.((((.....(((((...))))))))).)))))))))))))},(((..((.(((({(((((((((({...{,({,,{{({{{(,(,.((((((.,.{{{...,((((({.{(((.,{(,(((((,((((,{({,,{(((({{((((..(({,{.{,,.,,)}))))}))))))))})),}|{||.,,})}}}|||,|.|{....)).}.,}|{{,(((((((((({...})}||))))))},|))}}||{{,.{{...((({({(((((((((...((.......))..)))))))))......)))))),,||.|{||,.|)))),((((((||((((((.(((....(((((..||||.....,,)}..)))))...))).))))}}.),.))))))......||,.,,}}..||}|||{|{{|||{|||}|||||{,...,)))))},.}}}|.||||..,{{..{||.,,(((((((..(((((.((((({(,....)))))))((((....))))..((((...)))).)))))..))))))).})),)))|||||||{,......,,)||||||||{{,.{{||,....,||,}}||||}|||}}},.)))))),,..,}}))))))))))))),})).))))).)))))})...)))),,))))){((((((((({{{,...}}}}(((((..........)))))((((..((((((....)))))).))))..)))))))))|(((((.,..(((((((((((((.(((((((((......))}}..((({....,))}.({{(.,....{{{.......)))..})))....,,..))))))))).)))))))))...,.))))),.......))))))||{{,,,...})))..))))..))))))))))))))))}((((({(((........)))}))))).............,|{.........,,.
Transcripts
| ID | Sequence | Length | GC Content |
|---|---|---|---|
| NM_001243193.2 | GAGUGGGGGAGAGAGAGGAGACCAGGACAGCUGCUGAGACCUCUAAGAA… | 1059 nt | 0.5458 |
| NM_016583.4 | GAGUGGGGGAGAGAGAGGAGACCAGGACAGCUGCUGAGACCUCUAAGAA… | 1020 nt | 0.5490 |
| NM_130852.3 | GAGUGGGGGAGAGAGAGGAGACCAGGACAGCUGCUGAGACCUCUAAGAA… | 1075 nt | 0.5470 |
Summary
This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2014]
Forensic Context
No forensic context available.
Genomic Tracks
