Basic Information

Symbol
piR-hsa-28877
RNA class
piRNA
Alias
hsa-piR-28765 DQ598677.1 hsa_piRNA_25328 hsa_piR_020829 piR-36743 URS0000002D9E PIR59788
Location (GRCh38)
5:181188456-181188488
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Chronological age estimation
External database
piRBase piRNAdb RNAcentral

Sequence & Structure

Transcript
piR-hsa-28877
Sequence length
32 nt
GC content
0.5313

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-3.80 kcal/mol
Thermodynamic ensemble
Free energy: -4.37 kcal/mol
Frequency: 0.3968
Diversity: 4.88
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in humans demonstrated that the expression profiles of the piR-hsa-28877 collectively exhibited acceptable discriminating ability for most forensically relevant biological samples, including venous blood, menstrual blood, saliva, semen, vaginal secretions, and skin [Wang et al. DOI:10.1016/j.fsigen.2019.07.015]. A study in human venous blood samples demonstrated that the piR-hsa-28877 is positively correlated with aging (Pearson r = 0.599 in massively parallel sequencing and r = 0.112 in RT-PCR) and was identified as one of five age-related piRNAs for forensic age estimation [Fang et al. DOI:10.1007/s00414-023-03028-8]. In a separate characterization of human forensic stains, the piR-hsa-28877 was newly identified as a stable reference gene for small RNA profiling across six body fluids/tissues, supporting its utility in data normalization [Liu et al. DOI:10.3390/genes13091530].