A study in humans demonstrated that the piR-hsa-27493 is a potential biomarker for distinguishing forensically relevant biological fluids [Wang et al. DOI:10.1016/j.fsigen.2019.07.015]. A review further confirms its potential for distinguishing venous blood from menstrual blood and for distinguishing saliva from vaginal secretions in human samples [Li et al. DOI:10.1093/fsr/owad003].