Basic Information

Symbol
MHRT
RNA class
lncRNA
Alias
Myosin Heavy Chain Associated RNA Transcript Myheart NONHSAG014495.2 HSALNG0100037
Location (GRCh38)
14:23383229-23418482
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI OMIM RNAcentral

Transcripts

ID Sequence Length GC content
HSALNT0208263 CAGCUCAGCCUGCAGCAGGUUGUUGCGCCGCUCCACGAUGGCGAUGUUC… 370 nt 0.5946
HSALNT0208264 GCUUGGCUCGCUGGGUGGUGAAAUCAUUGAGGGAGCGUUGGGCCUCUUC… 328 nt 0.6311
HSALNT0208268 GAGACACUGGUCUGGAUCGGGUCGGUGGAGUGGGGGACUUACAUCCGUG… 207 nt 0.6039
HSALNT0289169 CUGGAGCUGGGACAGGUCAGCAUCCAUCUUCUUCUUCUGGUUGAUGAGG… 876 nt 0.5982
HSALNT0375696 UCCUCGGCCUGGCGCUUGUAGGCCUUGACCUUCAGUUGCAGCUUGUCCA… 410 nt 0.6171
HSALNT0375697 UCUGUCUGCUCCACCACGGCACGCAGCUCCUCCAGCUCAGCCUGCAGCA… 416 nt 0.6274
Summary

This gene encodes a spliced long non-coding RNA that may act as a cardioprotective agent in the heart. Based on a study of a similar gene in mouse, the encoded transcript may regulate chromatin remodeling by acting as a decoy to the BRG1 chromatin repressor complex thus preventing it from binding to its genomic targets. Blocking the actions of BRG1 could be crucial in protecting the heart from pathological hypertrophy. [provided by RefSeq, Dec 2014]

Forensic Context

A review of cardiovascular literature indicates that the MHRT is a long noncoding RNA with a protective role against pathological cardiac hypertrophy, functioning by inhibiting the Brg1-Hdac-Parp chromatin repressor complex and reducing myocardin acetylation and expression via HDAC5 [Chih-Fan Yeh et al. DOI:10.1186/s12929-020-00647-w].