Basic Information

Symbol
IGF2-AS
RNA class
lncRNA
Alias
IGF2 Antisense RNA IGF2-AS1 IGF2AS PEG8 Insulin-Like Growth Factor 2 Antisense 1 (Non-Protein Coding) IGF2 Antisense RNA 1 (Non-Protein Coding) Putative Insulin-Like Growth Factor 2 Antisense Gene Protein 1 Putative Insulin-Like Growth Factor 2 Antisense Gene Protein Insulin-Like Growth Factor II, Antisense Insulin-Like Growth Factor 2, Antisense IGF2 Antisense RNA (Non-Protein Coding) IGF2 Antisense Gene Protein 1 PEG8/IGF2AS, Imprinting IGF2 Antisense RNA 1 PEG8/IGF2AS Protein HSALNG0082197
Location (GRCh38)
11:2140501-2148666
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt RNAcentral

Transcripts

ID Sequence Length GC content
HSALNT0289463 UCCUAGGCCCGCGGGCUAGAGGCACUUUACCGCCCGGCGGGAGCGCCUC… 2068 nt 0.6378
HSALNT0361032 UCCCGGCGGAGUCCUAGGCCCGCGGGCUAGAGGCACUUUACCGCCCGGC… 1641 nt 0.6569
HSALNT0361033 GGCCCGCGGGCUAGAGGCACUUUACCGCCCGGCGGGAGCGCCUCUCCUC… 2063 nt 0.6384
HSALNT0361034 AUGAGCAAACGAAAGUGGCGCGGAUUUCGGGGCGCCCAGCAGGAGCGAG… 1867 nt 0.6422
HSALNT0361035 AGAGGCACUUUACCGCCCGGCGGGAGCGCCUCUCCUCCGCGUCCCUCGC… 2838 nt 0.6237
HSALNT0361036 AGAGGCACUUUACCGCCCGGCGGGAGCGCCUCUCCUCCGCGUCCCUCGC… 1982 nt 0.6443
Summary

This gene is expressed in antisense to the insulin-like growth factor 2 (IGF2) gene and is imprinted and paternally expressed. It is thought to be non-coding because the putative protein is not conserved and translation is predicted to trigger nonsense mediated decay (NMD). Transcripts from this gene are produced in tumors and may function to suppress cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

Forensic Context

A study in human brain tissue within a 27-hour postmortem period identified the IGF2-AS as a stable reference gene among over 90 candidate lncRNAs, validating its potential for postmortem interval estimation [Li et al. DOI:10.1093/fsr/owad003].