Basic Information

Symbol
BACE1-AS
RNA class
lncRNA
Alias
BACE1 Antisense RNA NCRNA00177 BACE1-AS1 BACE1 Antisense RNA (Non-Protein Coding) FJ573250 BACE1AS Non-Protein Coding RNA 177 NONHSAG009728.2 HSALNG0087449
Location (GRCh38)
11:117288453-117293571
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM RNAcentral

Transcripts

ID Sequence Length GC content
HSALNT0181744 ACUUGUGACCAAAGUGAACCACGGAGGUGUGGUCCAGGGGAAUCUCUAU… 2646 nt 0.4981
HSALNT0181745 UGACUCAUCUGUCUGUGGAAUGUUGUAGCCACAGUCUUCCAUGUCCAAG… 2552 nt 0.4796
HSALNT0181747 UCCCCCUGACUCAGGCUGGGACAUACCUGCGGAAGGAUGGUGAUGCGGA… 520 nt 0.5173
HSALNT0181748 GGCUCACCGCAACCUCCACCGUCCUGAGUUAAAGUGAUUCUCCUGUCUC… 804 nt 0.4851
HSALNT0181749 ACGAAGCAAGGCAGUGACUAGAGUCCAGACAUCAGAACUAGUUCCAUGU… 774 nt 0.4238
HSALNT0288891 GGCUCACCGCAACCUCCACCGUCCUGAGUUAAAGUGAUUCUCCUGUCUC… 825 nt 0.4800
HSALNT0365090 GUUCAACAUUAUGCUUUUAAGGAUUAGAUAGAAGAGGUCUCCUACCUAU… 4584 nt 0.4797
HSALNT0365091 GGCUCACCGCAACCUCCACCGUCCUGAGUUAAAGUGAUUCUCCUGUCUC… 796 nt 0.4899
Summary

This gene encodes an unspliced long non-coding RNA transcribed from the opposite strand to BACE1. The encoded transcript is thought to form an RNA duplex with BACE1 mRNA thereby regulating its expression and is also thought to promote post-transcriptional feed-forward regulation of BACE1. This may lead to increased levels of beta amyloid and increased senile plaque deposition, and therefore may play a role in the pathophysiology of Alzheimer's disease. [provided by RefSeq, Jan 2015]

Forensic Context

A review of non-coding RNAs in neurological diseases notes that the BACE1-AS triggers Aβ production and aggregation via BACE1 activity in Alzheimer's disease [Das et al. DOI:10.1080/21655979.2021.2003667], while a separate review on cardiovascular disorders reports that the BACE1-AS increases expression of toxic β-amyloid protein in endothelial cells and cardiomyocytes and stabilizes the BACE1 sense transcript to increase β-amyloid production in myocardial infarction [Chih-Fan Yeh et al. DOI:10.1186/s12929-020-00647-w].